Gas Chromatography-Mass Spectrometry (GC-MS)

Gas chromatography-mass spectrometry (GC-MS) is a destructive analytical technique that combines the separation capabilities of gas chromatography with the detection capabilities of mass spectrometry. GC-MS is used for the identification and quantification of different compounds in complex mixtures. GC-MS is a powerful tool for identifying unknown substances, and it is widely used in many industries, including pharmaceuticals, food safety, environmental monitoring, and biotechnology.


Introduction to Gas Chromatography-Mass Spectrometry (GC-MS)

Gas chromatography-mass spectrometry (GC-MS) is the synergistic combination of two different analytical methods applied in tandem to separate and identify different substances in a solid, liquid or gaseous sample. In GC-MS firstly gas chromatography (GC) separates the components of a sample and then the attached mass spectrometer (MS) provides information (mass-to-charge ratio [m/z]) that aids in the identification and structural elucidation of each component. The MS instrument determines the mass-to-charge ratio (m/z) of the separated components providing information about the molecular weight and elemental composition of the components, as well as elucidating the chemical structures of sample components. The GC-MS technique is utilized to study liquid, gaseous or solid samples. Analysis of different samples may need instruments of different capacities. For particular samples, while the gas chromatography system may remain the same, different types of mass spectrometers may be employed for different types of analyses depending on the level of selectivity and sensitivity required for GC-MS analysis.

Principle and Methodology of Gas Chromatography-Mass Spectrometry (GC-MS)

In GC-MS, the separation of compounds is done by gas chromatography followed by their identification and quantification by mass spectrometry technique in testing labs. The methodology of GC-MS involves the following steps: (a) sample preparation, (b) injection into the gas chromatograph, (c) separation of components within the column, (d) detection by mass spectrometry, and (e) data analysis. A liquid sample (prepared by extraction and concentration techniques) is injected into a heated column containing an inert carrier gas such as helium or nitrogen. As the sample passes through the column, it is separated into its component parts based on their individual boiling points. The separated compounds are then detected by a mass spectrometer which measures their mass-to-charge ratio (m/z); this process is known as mass spectrometric detection or MSD. Finally, data analysis techniques such as peak integration are used to identify and quantify each compound in the sample.

The instrumentation required for GC-MS includes a gas chromatograph with an appropriate detector such as flame ionization detector (FID) or electron capture detector (ECD). A mass spectrometer is connected to the gas chromatograph for detecting compounds after they have been separated within the column, The mass spectrometer can either be directly connected or can be connected via an interface device such as an atmospheric pressure chemical ionization source (APCI). Various other accessories may be required depending on the application such as automated injectors for injecting samples into columns at precise temperatures and flow controllers for controlling carrier gases at specific flow rates during analysis.

Instrumentation for GC-MS

Uses of Gas Chromatography-Mass Spectrometry (GC-MS)

GC-MS has many uses across various industries such as pharmaceuticals (active ingredient testing), food safety testing (pesticide residue analysis), environmental monitoring (VOCs), forensics (toxicology screening), biotechnology (biomarker discovery) and others. It has also been widely used in research laboratories for identifying unknown substances or quantifying known substances in complex mixtures. It is one of the most accurate tools for analyzing environmental samples

Advantages of Gas Chromatography-Mass Spectrometry (GC-MS)

Compared to other analytical techniques, gas chromatography-mass spectrometry (GC-MS) has several advantages such as high sensitivity (detection limits down to parts per trillion), high selectivity (ability to distinguish between closely related compounds), and high accuracy (low error rates). GC-MS also offers fast analysis times with results typically available within minutes rather than hours or days with other techniques. Finally, GC-MS is used for the analysis of a wide range of samples including liquids, solids, gases and volatile organic compounds (VOCs).

Disadvantages of Gas Chromatography-Mass Spectrometry (GC-MS)

Disadvantages of this technique over other analytical methods include cost of instrumentation/maintenance/operation and limited dynamic range due to low signal intensity at higher concentrations of analytes compared to lower concentrations of analytes which can lead to inaccurate results if not corrected properly using internal standards or standard addition methods.


Where can I get the gc ms tested?

You can share your gc ms testing requirements with MaTestLab. MaTestLab has a vast network of material testing laboratories, spread across the USA and Canada. We support your all material testing needs ranging from specific gc ms test to various testing techniques.

How much do I need to pay for the gc ms test?

Please contact us for a detailed quote for your gc ms testing needs. Cost incurred to carry out different gc ms testing methodology depends on the type of raw material; number of samples, coupons, or specimens; test conditions, turn around time etc. Costs of some ASTM testing methods start from $100 and the final value depends upon the factors listed above. Please contact us for the best and latest prices.

How many samples are required for gc ms?

The required number of samples or specimens should comply with the procedure given in the gc ms standard. However, the MaTestLab operations team can assist you for your special requirements once you share your testing details with us.

How much discount can I get on the gc ms test?

MaTestLab has a vast testing laboratory network, hence we bring you the best testing facilities in a cost-effective way. We offer considerable discounts (15-20%) to our returning customers based on test volume and frequency.

How many days will it take to complete the gc ms test?

The turnaround time for gc ms test methodology depends upon the test procedure mentioned in the standard test document. However, we at MaTestLab understand your research requirements and hence try to get your test completed within the least possible time.

Where can I get the gc ms tested?

You can share your gc ms testing requirements with MaTestLab. MaTestLab has a vast network of material testing laboratories, spread across the USA and Canada. We support your all material testing needs ranging from specific gc ms test to various testing techniques.

MaTestLab Inc. offers accessible, quick, and affordable material testing, product testing, and failure analysis services. We support your on-demand testing and expert consultation needs with the help of our extensive network of material testing laboratories situated in the US and other parts of the world.
We offer destructive and non-destructive tests over a range of mechanical, electrical, chemical, thermal, optical, corrosion, radiation, and biological testing methodologies defined by ASTM, ISO and other organizations.
We help you evaluate and ensure your product quality and performance with standard and custom-made testing solutions. All the tests are done at well-equipped testing laboratories using standard testing methods for best output and satisfaction.
Failure analysis ensures high levels of quality in every manufacturing process. We help you with getting the best failure or root cause analysis to determine the cause of the failure. The results help you identify means to prevent failure recurrences.
Process for testing
  • STEP 01

    You share your testing requirements

  • STEP 02

    You share your sample(s)

  • STEP 03

    We deliver your test reports

Get your testing done

Let us known your testing requirements and we will be right back with a solution.

Let us root for each other. Collaborate to grow, expand, and accelerate our businesses.

Please share your requirement with us